SUTEMIZUVCHILAR HUJAYRALARIDA NOORGANIK POLIFOSFATLAR DARAJASINING HUJAYRADAGI ENERGETIK METABOLIZM FAOLLIGIGA BOG‘LIQLIGINI O‘RGANISH
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Noorganik polifosfatlar (poli-F) ATF molekulasi bilan tuzilish jihatdan o‘xshashligi tufayli uzoq vaqtdan beri sutemizuvchilar
hujayralarida ATF molekulasining analogi/alternativi sifatida ko‘rib kelingan. Biz ushbu ishimizda glutamat+malat yoki suksinat
qo‘shilishi orqali ajratilgan mitoxondriyalarning bioenergetikasini rag‘batlantirish poli-F darajasining oshishiga olib keldi va bu
jarayonlar ATF mavjudligiga bog‘liq emasligini ko‘rsatdik. Intakt hujayralar bilan o‘tkazilgan tajribalar shuni ko‘rsatdiki,
hujayralarni glyukozasiz muhitda inkubatsiya qilish poli-F darajasining pasayishiga olib keldi, glyukoza qo‘shilishi
hujayralardagi poli-F darajasining sezilarli darajada oshishiga yordam berdi. Barcha jarayonlar rotenon va oligomitsinning
mavjudligiga bog‘liq ravishda kechdi.
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7. Rustamova, S. I., Tsiferova, N. A., Khamidova, O. J., Kurbannazarova, R. S., Merzlyak, P. G., Khushbaktova, Z. A.,
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