INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL
This study investigated the antihypertensive activity of MPSGA (Mono-potassium salt of glycyrrhizic acid):Naringenin 4:1 and
MPSGA:Apigenin 4:1 complexes, as well as extracts obtained from Phlomoides isochila (IM-1) and Pyrus pyraster fruits, in an
experimental model of hypertension. The experiments were performed on outbred white rats weighing 190–200 g. Arterial blood
pressure was measured non-invasively using the Tail Cuff method. The tested compounds were administered at doses of 20, 40,
and 60 mg/kg, and their effects on systolic and diastolic blood pressure parameters were comparatively evaluated.
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