BIS-AMINONITRILLARNING ISHQORIY VA KISLOTALI GIDROLIZI ASOSIDA BIS-AMINOKISLOTALAR SINTEZI
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Mazkur tadqiqotda 2,2′-(butan-1,4-diilbis(azandiil))bis(2-metilpropannitril)ning ishqoriy va kislotali gidroliz jarayonlari
o‘rganildi. Reaksiyalar natriy gidroksidning spirtli va suvli eritmalarida hamda xlorid kislotaning suvli eritmasida olib borildi.
Reaksiya muhiti, harorat va jarayon davomiyligining mahsulot unumiga ta’siri tahlil qilindi. Barcha sharoitlarda boshlang‘ich bisaminonitrilning to‘liq konversiyasi kuzatilib, tegishli bis-aminokislota 86–94 % unum bilan mahsulot olindi. Mahsulotning tuzilishi
IQ-spektroskopiya va mass-spektrometriya usullari yordamida tasdiqlandi.
1. Alfano A.I., Sorato A., Ciogli A., Lange H., Brindisi M. Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines
in flow: reaction optimization and sustainability aspects. Journal of Flow Chemistry. 2024;14(1):197–210. DOI:
10.1007/s41981-023-00279-9.
2. Yamaguchi T., Asano Y. Nitrile-synthesizing enzymes and biocatalytic synthesis of volatile nitrile compounds: A review.
Journal of Biotechnology. 2024;384:20–28. DOI: 10.1016/j.jbiotec.2024.02.007.
3. Zhou S.P., Xue Y.P. Maximizing the potential of nitrilase: Unveiling their diversity, catalytic proficiency, and versatile
applications. Biotechnology Advances. 2024.
4. Torri D., Bering L., Yates L.R.L., Angiolini S.M., Xu G., Cuesta-Hoyos S., Shepherd S.A., Micklefield J. Enzymatic
Cascades for Stereoselective and Regioselective Amide Bond Assembly. Angewandte Chemie International Edition.
2025;64:e202422185. DOI: 10.1002/anie. 202422185.
5. Sun W. et al. Recent progress of activator of an industrially important nitrile hydratase. 2024. 6
6. Chuliyev J.R., Kodirov A.A., Mamaraxmonov M.X., Asqarov I.R., Synthesis, crystal structure of mono- and bis- α-
aminonitriles and classification based on chemical composition. Austrian Journal of Technical and Natural Sciences №.9-10
2020. Page №.47-52
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