ALKYNYLATION REACTIONS OF SOME HETEROATOMIC ALDEHYDES IN THE PRESENCE OF ACETYLENE
Abstract
For the first time, using the ProPhenol/Me2Zn/THF catalytic system, the process of synthesis of new types of acetylene alcohols was carried out based on the alkynylation reaction with heteroatomic substituents containing in their molecule - 1-(thiophen-2yl)-ethanone, 1-(3-methylthiophen-2-yl)-ethanone, 1-(5-chlorothiophen-2-yl)-ethanone, 1-(5-bromothiophen-2-yl)-ethanone, 1(furan-2yl)-ethanone, 1-(pyridinyl-4)-ethanone enantioselective reaction of with acetylene. The influence of molar ratios of starting substances, reaction duration, temperature, nature and amount of catalyst and solvents on the product yield was studied. Based on the influence of heteroatoms in the aldehyde molecule on the yield of the product, the efficiency of the production of acetylene alcohols was determined, and their composition, purity and structure were identified using physicochemical methods.
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