FENIL-2-METILFENOKSIPROPIONATNI SINTEZ QILISH USULI VA UNING TUZILISHINI ANIQLASH
This method for synthesizing phenyl-2-methylphenoxypropionate was developed. The effect of solvents on the efficiency of the reaction during the synthesis process was analyzed in detail. Solvents such as benzene, acetone, dioxane, dimethylformamide (DMF), and dimethylsulfoxide (DMSO) were selected. According to the experimental results, the highest result was recorded in the DMSO solution, with phenyl-2-methylphenoxypropionate formed in a yield of 86%. This is explained by the high dielectric constant and good solvation properties of the DMSO solvent. The structure of the synthesized new organic substance - phenyl-2-methylphenoxypropionate - was confirmed by modern instrumental methods. The structure of the synthesized new organic substance - phenyl-2-methylphenoxypropionate was confirmed using modern IR, ¹H NMR and 13C NMR spectra.
1. Yamali C., Tugrak M., Gul H.I., et al. The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes. Journal of enzyme inhibition and medicinal chemistry. 2016. V.31(6). -P.1678-1681.
2. Fishman A, Tao Y, Wood T. K. Toluene 3-Monooxygenase of Ralstonia pickettii PKO1 Is a para-Hydroxylating Enzyme//J.Bacteriology. 2024. V.186(10). -P.3117–3123.
3. Mamatkulov N.N., Yakubov L E. Synthesis of o-tolylphenoxyastatin through a nucleophilic substitution reaction from o-toluoyl chloride and examination of it’s biological activity/ Nat. Volatiles & Essent. Oils, 2021. -№ 8(5). -P. 12125-12131.
4. Mamatkulov N.N., Yakubov L. E. Madusmanova N.K., Khoshimkhanova M.A. Method for the Synthesis and Bioavailability of Phenol-4-Methoxyphenoxy-acetate by Nucleophilic Exchange Reaction/ Nat. Volatiles & Essent. Oils, 2021. -№ 8(5). –P. 12140-12144.
5. Mamatkulov N.N., Khoshimkhаnova M.A., Devolopment of the mechanism of action and reaction of O-chloracetylation/ International Journal of advanced Research in Science, Engineering and Technology. 2020.-Vol. 7. –Is. 1. -P. 12636-12639. (IF-6.684).
6. R. Roswanda., A.D. Sirampun., R. Mukti. A Straightforward Selective Acylation of Phenols over ZSM-5 towards Making Paracetamol Precursors // Bulletin of Chemical Reaction Engineering and Catalysis. 2018. V.13. №3 -P. 472-487.
7. W-J. Liao., S-Y. Lin., Y-S Kuo. Site-Selective Acylation of Phenols Mediated by a Thioacid Surrogate through Sodium Thiosulfate Catalysis// Org. Lett. 2022. V.24. №23. -P. 4207–4211.
8. Чориев А. У., Бердимуродов Э. Т. Тошпулатов Т. И. Садикова С. Б Синтез 1,4-фенилен дикарбоксиметиленгликолята//Universum: химия и биология. 2020. Bып. №5(71). -С. 54-58.
9. Г.А.Гулиева., Г.М.Аскарова., А.М.Магеррамов., М.Р.Байрамов., М.А.Агаева. Исследование бактерицидных и противогрибковых свойствновых пиридиниевых производных на основе фенольных оснований Манниха//Биомедицина. 2020. Т. 18. №3. -С.16-20.
10. Г.А.Гулиева., Г.М.Аскарова., А.М.Магеррамов., М.Р.Байрамов., М.А.Агаева. Исследование бактерицидных и противогрибковых свойствновых пиридиниевых производных на основе фенольных оснований Манниха//Биомедицина. 2020. Т. 18. №3. -С.16-20.
Copyright (c) 2025 «ACTA NUUz»

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.






.jpg)

1.png)





