REACTION OF O-XYLENE WITH 2-CHLOROPROPIONYL CHLORIDE IN THE PRESENCE OF FeCl₃·6H₂O CATALYST
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In this article, for the first time, the reaction of o-xylene with 2-chloropropionyl chloride in the presence of the catalyst FeCl₃·6H₂O has been carried out, and the influence of reagent ratios as well as reaction conditions on the composition of the products has been scientifically substantiated. The composition of the obtained products was studied by GC, and each compound was isolated by column chromatography. The structures of the isolated compounds were determined using IR, ¹H NMR, and ¹³C NMR spectroscopy. It was established that the highest product yield is achieved when the reaction is conducted at a 1:1 molar ratio of o-xylene to 2-chloropropionyl chloride.
1. Choudhary V. R., Jana S. K. Acylation of aromatic compounds using moisture insensitive mesoporous Si-MCM-41 supported Ga2O3 catalyst //Syn. com. – 2002. – Т. 32. – №. 18. – С. 2843-2848. 2. Vasant R. Choudhary, Suman K. Jana. Acylation of Aromatic Compounds Using Moisture Insensitive Mesoporous Si-MCM-41 Supported Ga2O3 Catalyst. Div. Chem. Eng., Natl. Chem. Lab., 2010. 008, India https://doi.org/10.1002/chin.200252096 3. Tamaddon F., Rashidi H. ZnCl2: 2HOAc: A deep eutectic solvent for the Friedel–Crafts acetylation of poly-phenols and chemo-selective protection of alcohols //Research on Chemical Intermediates. – 2023. – Т. 49. – №. 8. – С. 3589-3603. 4. Di Carmine G., Abbott A. P., D'agostino C. Deep eutectic solvents: alternative reaction media for organic oxidation reactions //Reaction Chemistry & Engineering. – 2021. – Т. 6. – №. 4. – С. 582-598.
5. Маматкулов Н.Н. Влияние соотношения реагентов и катализатора на выход реакции хлорацетилирования фенола и изомерных крезолов // UNIVERSUM: Технический науки. Научный журнал. Москва, 2021. -№4 (82). -С. 77-80.
6. Маматкулов Н.Н. Об одной задаче синтез реакции ацетилирование м-крезола // Ясауи университетінің хабаршысы. Қозоғистон, 2018. -№2. –С. 43-48.
7. Choriev A., Abdushukurov A.K., Jurayev R., Jurayeva M. Di(2-izopropil-5-metilfenilkarboksimetilen) oksalat sintezi//Kimyo va kim. texn. jurn. Toshkent, 2023, №1, B. 33-35.
8. Маматкулов Н.Н. Об одной задаче синтез реакции ацетилирование м-крезола // Ясауи университетінің хабаршысы. Қозоғистон, 2018. -№2. –С. 43-48.
9. Mamatkulov N.N., Pattaeva Z. S. Testing the biological activity of some properties of phenylchloracetate in the pass online program // International Journal of Economy and Innovation. 2023.-V. 37. -P. 74-78
10. S. Lerch., S. Fritsch., T. Strassner. Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)// Beilstein J. Org. Chem. 2023. V.19. -P. 212–216.
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