OPTIMIZED CONDITIONS FOR THE SYNTHESIS OF PYRIDINE N-OXIDE AS A NITROGEN-CONTAINING ORGANIC COMPOUND AND ITS REACTION MECHANISM
This article discusses the applications of pyridine derivatives in agriculture, medicine, and industry, as well as modern synthetic
methods for their preparation. The low reactivity of pyridine as a π-electron-deficient heterocyclic compound toward electrophilic
reactions and the dependence of its oxidation processes on reaction conditions were analyzed. The study investigates the oxidation
of pyridine in the presence of hydrogen peroxide and formic acid, and the step-by-step mechanism of pyridine N-oxide formation
is described. The influence of reaction conditions (temperature, time, and reagent ratio) on product yield was determined, with
optimal conditions identified as 80°C and 12 hours, achieving a yield of 84–86%. The structure of the obtained product was
confirmed by IR spectroscopic analysis. The results demonstrate an efficient and optimized method for the synthesis of pyridine
N-oxides.
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