СИНТЕЗ НОВЫХ ПРОИЗВОДНЫХ ИЗОКСАЗОЛА КАК ВЫСОКОЭФФЕКТИВНЫХ ИНГИБИТОРОВ АCHE И BCHE
Данное исследование посвящено получению трициклических производных изоксазола, являющихся изостерическими
аналогами дезоксивазицинона и хиназолинона. Структуры синтезированных соединений были подтверждены
соответствующими физико-химическими и спектральными методами анализа. Ингибирующее действие синтезированных
соединений в отношении ферментов ацетилхолинэстеразы (AChE) и бутирилхолинэстеразы (BChE) было изучено с
использованием методов молекулярного докинга. Анализ результатов докинга показал, что соединение 5c и 5d проявило
наибольшую аффинность связывания с ацетилхолинэстеразой, тогда как соединение 5e продемонстрировало наибольший
потенциал связывания с бутирилхолинэстеразой.
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