ACHE VA BCHE INGIBITORLARI SIFATIDA YANGI IZOKSAZOL HOSILALARINING SINTEZI
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Ushbu tadqiqot deoksivazitsinon va xinazolinonning izosterik analoglari sifatida trisiklik izoksazol hosilalarini yaratishni taqdim
etadi. Yangi yaratilgan birikmalarning tuzilmalari tegishli fizik-kimyoviy va spektral tahlillar orqali tekshirildi. Sintez qilingan
birikmalarning atsetilxolinesteraza (AChE) va butirilxolinesteraza (BChE) fermentlariga ingibitiv ta’siri molekulyar doking
tadqiqotlari orqali baholandi. Doking tahlili shuni ko‘rsatdiki, 5c va 5d birikmasi atsetilxolinesteraza uchun eng yuqori bog‘lanish
yaqinligini, 5e birikmasi esa butirilxolinesteraza uchun eng muhim bog‘lanish potentsialini namoyish etdi.
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