SYNTHESIS OF NOVEL ISOXAZOLES AS POTENT ACHE AND BCHE INHIBITORS
This research presents the creation of tricyclic isoxazole derivatives as isosteric counterparts of deoxyvasicinone and quinazolinone.
The structures of the newly created compounds were verified through relevant physicochemical and spectral analyses. The
inhibitory effects of the synthesized compounds on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were
assessed through molecular docking studies. Docking analysis indicated that compound 5d and 5c exhibited the highest binding
affinity for acetylcholinesterase, while compound 5e displayed the most significant binding potential for butyrylcholinesterase.
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