SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL
5-Fluorouracil and its derivatives have been used for many years in the treatment of tumor diseases (gastrointestinal,
gynecological, head and neck, breast cancer). 5-Fluorouracil against cancer it is a powerful agent and at the same time has many
harmful properties. In this work, in order to reduce the toxicity of 5-FU, it was first exposed to formalin and a compound of 5-FU
with methylol group was obtained. Then, by treating this compound with different carboxylic acids (formic, acetic and benzoic),
derivatives of 5-FU were synthesized. The analysis of the obtained products was studied by IR, UV, HPLC and gas
chromatograms.
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