5 – FTORURATSILNING YANGI HOSILALARI SINTEZI
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5-Ftoruratsil va uning hosilalari o’sma kasalliklar (oshqozon-ichak, ginekologik, bosh va bo'yin, ko'krak saratoni)ini davolashda
uzoq yillardan buyon foydalanib kelinadi. 5-Ftoruratsil saraton kasalliklarga qarshi kuchli vosita bo’lib shu bilan bir vaqtda
ko’plab zararli xususiyatlarga ega.Ushbu ishda 5-FU ning zaharlilik xususiyatini kamaytirish uchun, unga dastlab formalin ta’sir
ettirildiva metilol guruh saqlagan 5-FU ning birikmasi olindi. So’ngra shu birikmaga turli karbon kislotalar (chumoli,sirka va
benzoy) bilan ishlov berilganda 5-FU ning hosilalari sintez qilindi.Olingan mahsulotlarning tahlili IQ,UB,YuSSX va gaz
xromatografiyasi usullari orqali o‘rganildi.
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Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Ann. Oncol., 2004, 15, P. 1025-1032.
6. Chiara Focaccetti, Antonino Bruno, Elena Magnani, Desirée Bartolini, and all Effects of 5-Fluorouracil on Morphology, Cell
Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes. Plos One. 2015;
10(2): e0115686. Published online 2015
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treatment.MedChemComm,2016, 7. P. 378-385
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Derivatives. Int. J. Electrochem. Sci.,2011, P 1669 – 1678.
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acrylamide) hydrogels: in vitro drug delivery studies. Eur. Polym. J. 2000, 36, 111–122.
10. Wei-Ming Zhou, Rong-Rong He, Jian-Tao Ye, Na Zhang, De-Yu Liu. Synthesis and Biological Evaluation of New 5-
Fluorouracil Substituted Ampelopsin Derivatives.Molecules 2010, 15, P 2114-2123; doi:10.3390/molecules15042114.
11. Zhi-Yong Tian , Gang-Jun Du , Song-Qiang Xie , Jin Zhao , Wen-Yuan Gao ,
12. and Chao-Jie Wang - Synthesis and Bioevaluation of 5-Fluorouracil
13. Derivatives . Molecules 2007, 12, P 2450-2457.
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