SYNTHESIS OF KETONES BASED ON OXIDATION OF ACETYLENE ALCOHOLS CONTAINING HALOGEN SUBSTITUTETS
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Synthesis of the corresponding ketones by oxidation of acetylene alcohols containing halogen substituents. The object of study was acetylene alcohols containing halogen substituents, including 1-(2-chlorophenyl)-3-phenylpropyn-2-ol-1 (1a), 1-(2,4-dichlorophenyl)-3-phenylpropyn-2-ol-1 (2a), 1-(4-bromophenyl)-3-phenylpropyn-2-ol-1 (3a) acetylene alcohols were selected. The oxidation process of acetylene alcohols 1a, 2a and 3a, chosen as the object of study, was carried out for the first time in open air without the presence of a catalyst. As a result, the corresponding ketones are formed, including 1-(2-chlorophenyl)-3-phenylpropyn-2-one-1 (1b), 1-(2,4-dichlorophenyl)-3-phenylpropyn-2-one-1 (2b) and 1-(4-bromophenyl)-3-phenylpropyn-2-one-1 (3b) were synthesized in various yields.
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