GALOGEN O‘RINBOSARLAR SAQLAGAN ATSETILEN SPIRTLARINI OKSIDLASH ASOSIDA KETONLAR SINTEZI
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Tarkibida galogen o’rinbosarlari bo’lgan atsetilen spirtlarini oksidlash yo’li bilan tegishli ketonlarni sintez qilish. Tadqiqot ob’ekti sifatida galogen o‘rinbosarlar saqlagan atsetilen spirtlari, jumladan 1-(2-xlorfenil)-3-fenilpropin-2-ol-1 (1a), 1-(2,4-dixlorfenil)-3-fenilpropin-2-ol-1 (2a) va 1-(4-bromofenil)-3-fenilpropin-2-ol-1 (3a) asetilen spirtlari tanlangan. Tadqiqot ob’ekti sifatida tanlangan 1a, 2a va 3a atsetilen spirtlarining oksidlanish jarayoni birinchi marta katalizator ishtirokisiz ochiq havoda o’tkazildi. Natijada, 1-(2-xlorofenil)-3-fenilpropin-2-on-1 (1b), 1-(2,4-dixlorfenil)-3-fenilpropin-2-on-1 (2b) va 1-(4-bromofenil)-3-fenilpropin-2-on-1 (3b) kabi mos ravishdagi turli unumdorlikda hosil bo‘ldi.
Санъат САМАТОВ, Одилжон ЗИЯДУЛЛАЕВ, Саида АБДУРАХМАНОВА, Гузал ОТАМУХАМЕДОВА, & Фарход БУРИЕВ,. (2024). GALOGEN O‘RINBOSARLAR SAQLAGAN ATSETILEN SPIRTLARINI OKSIDLASH ASOSIDA KETONLAR SINTEZI. «ВЕСТНИК НУУз», 3(3.1), 438–442. https://doi.org/10.69617/nuuz.v3i3.1.1870
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13. Samatov S., Ikramov A., Abdurakhmanova S., Ziyadullayev O., Otamukhamedova G. Synthesis of aromatic acetylene alcohols based on benzaldehyde and its halogenated products benzaldehyde and its halogenated product. Chem. and Chem. Eng., 2022, 1, 42-48.
14. D. Filimonov, V. Poreykov. Forecast of the spectrum of biological activity of organic compounds. Rus. Сhem. J., 50/2, 66-75, 2006.
2. Ming N., Rui W., Zhi-jian H., Bin M., Chao-shan D., Lei L., Chao Ch. Synthesis of New C2-Symmetrical Bissulfonamide Ligands and Application in the Enantioselective Addition of Alkynylzinc to Aldehydes and Ketones. Adv. Synth. Catal. 2005, 347, 1659 – 1665.
3. Otamuxamedova, G.Q., Ziyadullayev O.E., Shmid E., Maniecki T. Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium. Chem. and Chem. Eng., 2019, 2, 30-36.
4. Wang Y., DuBois J., Hedman B., Hodgson K. Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity. Science, 1998, 279, 537-540.
5. Que L. Jr., Tolman W.B. Biologically inspired oxidation catalysis. Nature, 2008, 455, 333-340.
6. Largeron M., Fleury M.B. Bioinspired Oxidation Catalysts. Science, 2013, 339, 43 – 44.
7. B. L. Ryland, S. S. Stahl. Practical Aerobic Oxidations of Alcohols and Amines with Homogeneous Copper/TEMPO and Related Catalyst Systems. Angew. Chem. Int. Ed. 2014, 53, 8824 – 8838.
8. Allen S. E., Walvoord R. R., Padilla-Salinas R., Kozlowski M. C. Aerobic Copper-Catalyzed Organic Reactions. Chem. Rev. 2013, 113, 6234-6458.
9. Xu B., Lumb J., Arndtsen B. A TEMPO-Free Copper-Catalyzed Aerobic Oxidation of Alcohols. Angew. Chem. 2015, 127, 1-5.
10. Cainelli C., Cardillo C. Chromium Oxidants in Organic Chemistry. Springer, Berlin, 1984, 118.
11. Sato K., Aoki M., Noyori R., A "Green" Route to Adipic Acid: Direct Oxidation of Cyclohexenes with 30 Percent Hydrogen Peroxide. Science, 1998, 281. 1646.
12. Brink G.J., Isabel W., Arends C. E., Sheldon R.A. Green, Catalytic Oxidation of Alcohols in Water. Science. 2000, 287. 1636-1639.
13. Samatov S., Ikramov A., Abdurakhmanova S., Ziyadullayev O., Otamukhamedova G. Synthesis of aromatic acetylene alcohols based on benzaldehyde and its halogenated products benzaldehyde and its halogenated product. Chem. and Chem. Eng., 2022, 1, 42-48.
14. D. Filimonov, V. Poreykov. Forecast of the spectrum of biological activity of organic compounds. Rus. Сhem. J., 50/2, 66-75, 2006.
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