ИЗУЧЕНИЕ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ ИЗОМЕРОВ 2-ХЛОР-N-ТОЛИЛАЦЕТАМИДА В ПРОГРАММЕ PASS ONLINE
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Biological activity of chloro-N-tolilasetamide, 2-chloro-N-o-tolilasetamide, 2-chloro-N-m-tolilasetamide, and 2-chloro-N-p-tolilasetamides were synthesized as a result N-chlorocetilchloride reaction was studied in the PASS online program. The negative and toxicity effects of chloro-N-tolilasetamide isomers on the body, the values of Pa and Pi, have been identified. Additionally, the effects of chloro-N-tolilasetamide isomers on cardiovascular and hepatobiliar systems, the results of the cytoseharcity of the substance in relation to cancer cells, the study of activity against viruses and fungi, and the results were compared. Results were revealed that chloro-N-о-tolilasetamide and chloro-N-p-tolilasetamides are close biological activity to the above diseases and had only one isomeres of activity for some diseases
В.В.Поройков, Д.А.Филимонов. Компютерный прогноз биологической активности химических соединений как основа для поиска и оптимизации базовых структур новых лекарств. http://www.chem.msu.ru/rus/publ/ Poroykov/ welcome.html
Д.А. Филимонов, Д.С. Дружиловский, А.А. Лагунин- Компютерный прогнозирование спектров биологической активности химических соединений: Возможности и ограничения. http://www.bmc-rm.org/index.php/bmcrm/ article/ download/4/4 inline=1
Poroikov, V. V., Filimonov, D. A., Borodina, Yu. V., Lagunin, A. A. & Kos, A. Robustness of biological activity spectra predicting by computer program PASS for non-congeneric sets of chemical compounds.// Journal of Chemical Information and Computer Sciences,-2000. -Vol. 40. (6). -P1349-1355.
https://www.way2drug.com/passonline/index.php
Veber, D. F.; Johnson, S. R.; Cheng, H. U.; Smith, B. R.; Ward, K. W.; Kopple, K. D. Molecular properties that influence the oral bioavailability of drug candidate // J. Med. Chem., -2002. -Vol. 45.-P. 2615-2621.
Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J.; Adv. Drug Delivery Rev. 2001, 46, 3.
Satish V., Akolkar, Amol A., Nagargoje, Mubarak H., Shaikh, Murad Z., A. Warshagha |Jaiprakash N., Sangshetti, Manoj G., Damale, Bapurao B., Shingate. New N‐phenylacetamide‐linked 1,2,3‐triazole‐tethered coumarin conjugates: Synthesis, bioevaluation, and molecular docking study. //Arch Pharm., -2020, 11july
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