AYRIM ATSETILEN SPIRTLARINING 3-METILENIZOINDOLIN-1-ON BILAN KONDENSATSIYA REAKSIYASI
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The synthesis of isoindolinones by condensation reactions of acetylenic alcohols with 3-methyleneisoindolin-1-one using the AgOTf/PhMe catalytic system was studied. The selectivity and catalytic stability of the applied catalytic system on the efficiency of isoindolinones were investigated. The effect of the nature and amount of solvents, catalysts, reagents and substrates on the product yield in the synthesis of isoindolinones was systematically analyzed, and optimal conditions for the process were determined based on the results obtained.
1. Qian H., Huang D., Bi Y., Yan G. 2-Propargyl alcohols in organic synthesis // Advanced Synthesis Catalyze, 2019, Volume 361. Pp. 3240-3280.
2. Yagorla S., and Khan T. Iodocyclization of Propargyl Alcohols: Highly Facile Approach to Hetero/Carbocyclic Iodides // European Journal of Organic Chemistry, 2019, Volume 2019, Issue 25. Pp. 3989-4012.
3. X. Song, R. Yang, Q. Xiao Recent Advances in the Synthesis of Heterocyclics via Cascade Cyclization of Propargylic Alcohols // Advanced Synthesis and Catalysis, 2021. Volume 363, Issue 4. Pp. 852-876.
4. S.S. Abduraxmanova Ayrim aldegid va ketonlar asosida aromatik atsetilen spirtlari olinishi, xossalari, texnologiyalari, qo’llanilishi: Monografiya. – T .: 2024. – 192 bet.
5. Sudipta Ponra, Mukut Gohain, Rajashekar Donka, Johannes H. van Tonder, Barend C.B. Bezuidenhoudt. Al(OTf)3-catalyzed one-pot synthesis of pyrrolo [3,2-d] pyrimidinedione derivatives // Tetrahedron Letters, 2018. Volume 59. Pp. 2909-2912
6. X.Mao, X.Zhu, D.Li, L.Jiang, P.Liu Cascade reaction of alkynols with 1-(2-aminophenyl)prop-2-ynols to form a fused 5,5,6-tricyclic system: formation of four bonds in a single reaction // Chemical Communications, 2017. Volume 53. Pp. 8608-8611.
7. S.J.Gharpure, S.K.Nanda, Y.G. Shelke Metal-free Hydroalkoxylation-Formal [4+2] Cycloaddition Cascade for the Synthesis of Ketals // Chemistry European Journal, 2017, Volume 23. Pp. 10002-10017.
8. Y.Han, X.Li, M.Li, X.Zhu, Y.Liang Lewis Acid-Catalyzed Formal [3+3] Annulation of Propargylic Alcohols with 4-Hydroxy-2H-chromen-2-ones // Advanced Synthesis. Catalysts, 2018, Volume 360, № 15. Pp. 2796-2800.
9. M. Nogami, K. Hirano, M. Kanai, Ch. Wang, T. Saito, K. Miyamoto, A. Muranaka, M. Uchiyama Transition Metal-Free trans-Selective Alkynylboration of Alkynes // Journal of the American Chemical Society, 2017, Volume 139, № 36. Pp. 12358-12361.
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