4-METOKSIBENZOY KISLOTANING ANILIN VA TOLUIDIN IZOMERLARI BILAN REAKSIYALARI
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4-Metoksibenzoy kislotaning anilin va toluidin izomerlari bilan reaksiyalari erituvchisiz sharoitda qizdirish orqali olib borildi. Reaksiyalar katalizatorsiz va katalizator ortoborat kislotasi bilan olib borildi. Katalizator ishtirokida olib borilgan reaksiyalarda mahsulot unumi yuqori chiqanligi kuzatildi. Reaksiya oraliq bosqichlarida katalizator ortoborat kislotasining ishtiroki va oraliq mahsulotlarning hosil bo‘lish sxemasi taklif qilindi. Sintez qilingan amidlarning tuzilishi IQ spektroskopik usul bilan tasdiqlandi.
1. Wilhelm S., Carter C., Lynch M., Lowinger T., Dumas J., Smith R. A., Kelley S. Discovery and development of sorafenib:a multikinase inhibitor for treating cancer //Nature reviews Drug discovery, –2006. –Vol. 5. –No. 10. –P. 835-844.
2. Wilhelm S. M., Dumas J., Adnane L., Lynch M., Carter C. A., Schütz G., Zopf D. Regorafenib (BAY 73‐4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. International journal of cancer, –2011. –Vol. 129. –No. 1. –P. 245-255.
3. Ramurthy S., Aikawa M., Amiri P., Costales A., Hashash A., Jansen J. M., Verhagen J. Design and synthesis of 5, 6-fused heterocyclic amides as Raf kinase inhibitors. Bioorganic & medicinal chemistry letters, –2011. –Vol. 21. –No. 11. –P. 3286-3289.
4. El-Damasy A. K., Cho N. C., Kang S. B., Pae A. N., Keum G. ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles. Bioorganic & Medicinal Chemistry Letters, –2015. –Vol. 25. –No. 10. –P. 2162-2168.
5. Patel K. P. et al. Graphene oxide: a metal‐free carbocatalyst for the synthesis of diverse amides under solvent‐free conditions // Advanced Synthesis & Catalysis. – 2019. – Vol. 361. – №. 9. – P. 2107-2116.
6. Patel K. P., Gayakwad E. M., Shankarling G. S. Graphene Oxide as a Metal‐free Carbocatalyst for Direct Amide Synthesis from Carboxylic Acid and Amine Under Solvent‐Free Reaction Condition // ChemistrySelect. – 2020. – Vol. 5. – №. 27. – P. 8295-8300.
7. Zhu L. et al. Mechanochemistry, solvent-free and scale-up: Application toward coupling of acids and amines to amides // Results in Chemistry. – 2023. – Vol. 5. – P. 100882.
8. Khurramov E. N. et al. Synthesis of new amides based on the n-hydroxyacetylation of ptoluidine // International Journal of Mechanical and Production Engineering Research and Development. – 2020. – Vol. 10. – №. 3. – P. 6001-6016.
9. Burieva D. et al. Synthesis, crystal structure and Hirshfeld surface analysis of N-(4-methoxyphenyl) picolinamide // Structure Reports. – 2024. – Vol. 80. –№. 12.
10. Pingwah Tang. Discussion addendum for: boric acid catalyzed amide formation from carboxylic acids and amines: N-benzyl-4-phenylbutyramide // Org. Synth., -2012. -Vol. 89. -P. 432-437.
11. Arce G., Carrau G., Bellomo, A., Gonzalez D. Greener synthesis of an amide by direct reaction of an acid and amine under catalytic conditions. World J. Chem. Edu, -2015. -Vol. 3. -No. 1. -P. 27-29.
12. Xurramov E.N. Almashgan anilinlarning Glikol, diglikol va salitsil kislotalar bilan reaksiyalarini o‘rganish // Kimyo fanlari bo‘yicha falsafa doktori (PhD) dissertatsiyasi, O‘zMU, -2021. -P. 99-117.
13. Huy P., Zoller B. Boron Lewis Acid Catalysis: How to Synthesize Amides Atom-Efficiently // Nachrichten Aus Der Chemie (Journal of the German Chemical Society GDCh), – 2019. –Vol. 67. –No. 5. –P. 51-54.
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